Gloria J. Morris, Sashi Naidu, Allan K. Topham, Fran Guiles, Yihuan Xu, Peter McCue, Gordon F. Schwartz, Pauline K. Park, Anne L. Rosenberg, Kristin Brill and Edith P. Mitchell Differences in breast carcinoma characteristics in newly diagnosed African–American and Caucasian patients Cancer 110
Article first published online: 9 JUL 2007 | DOI: 10.1002/cncr.22836
Using their tumor registry, the authors found that African–American patients with breast cancer present with more aggressive features compared with Caucasian patients by virtue of higher stage of disease, tumor grade, and more estrogen receptor negativity, a finding that parallels data from the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) database. In addition, African–American patients appear to have a higher Ki-67 proliferation index and p53 expression than their Caucasian counterparts, which may explain the disparate behavior of their disease.
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