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Dirk Rades, Tiina Haatanen, Steven E. Schild and Juergen Dunst Dose escalation beyond 30 grays in 10 fractions for patients with multiple brain metastases Cancer 110

Version of Record online: 18 JUL 2007 | DOI: 10.1002/cncr.22906

Survival of and intracerebral control of disease in 257 patients who were treated with whole-brain radiotherapy at 10 fractions of 3 grays (Gy) each for 2 weeks were compared with 159 patients treated with 45 Gy in 15 fractions for 3 weeks or 40 Gy in 20 fractions for 4 weeks. Dose escalation beyond 30 Gy in 10 fractions does not appear to improve survival or local control but does increase the amount of treatment time and the cost of therapy.

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