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Yuanqing Ye, Scott M. Lippman, J. Jack Lee, Meng Chen, Marsha L. Frazier, Margaret R. Spitz and Xifeng Wu Genetic variations in cell-cycle pathway and the risk of oral premalignant lesions Cancer 113

Version of Record online: 29 SEP 2008 | DOI: 10.1002/cncr.23854

The authors used a pathway-based approach and a multifaceted approach to analyze high-order gene-gene and gene-smoking interactions. The results revealed that the alteration of risk of oral premalignant lesion by single-nucleotide polymorphisms in the cell-cycle control pathway can be attributed to smoking status. This pathway-based approach has the advantage of identifying the complex relationship between genetic polymorphisms and cancer susceptibility involving multiple factors.

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