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Gail J. Roboz, Ellen K. Ritchie, Tania Curcio, Juliette Provenzano, Rebecca Carlin, Michael Samuel, Beth Wittenberg, Madhu Mazumdar, Paul J. Christos, Susan Mathew, Sandra Allen-Bard and Eric J. Feldman Arsenic trioxide and low-dose cytarabine in older patients with untreated acute myeloid leukemia, excluding acute promyelocytic leukemia Cancer 113

Article first published online: 29 SEP 2008 | DOI: 10.1002/cncr.23855

The authors hypothesized that arsenic trioxide may augment the clinical activity of low-dose cytarabine in older patients with acute myeloid leukemia (AML), and they conducted a phase 1/2 study to determine the safety and efficacy of the combination. The results indicated that arsenic trioxide combined with low-dose cytarabine appeared to improve responses in elderly patients who had AML compared with either agent alone.

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