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Robert Goldsby, Cynthia Burke, Rajaram Nagarajan, Tianni Zhou, Zhengjia Chen, Neyssa Marina, Debra Friedman, Joseph Neglia, Paul Chuba and Smita Bhatia Second solid malignancies among children, adolescents, and young adults diagnosed with malignant bone tumors after 1976 Cancer 113

Article first published online: 29 SEP 2008 | DOI: 10.1002/cncr.23860

The cumulative incidence of solid organ second malignant neoplasms in 1686 patients with osteosarcoma and 1156 patients with Ewing Sarcoma treated on legacy Children's Cancer Group/Pediatric Oncology Group protocols from 1980 to 2005 was 1.4% (95% confidence interval, 0.6%-2%) at 10 years. Overall, the cohort was at a 3.7-fold increased risk of second solid tumors compared with the general population.

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