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Peng Hou, Meiju Ji and Mingzhao Xing Association of PTEN gene methylation with genetic alterations in the phosphatidylinositol 3-kinase/AKT signaling pathway in thyroid tumors Cancer 113

Version of Record online: 2 OCT 2008 | DOI: 10.1002/cncr.23869

Methylation of the PTEN gene promoter was analyzed in various types of thyroid tumors and found to be associated with activating genetic alterations in the phosphatidylinositol 3-kinase (PI3K)/AKT pathway. The findings suggest a self-enhancement mechanism for genetically activated signaling of the PI3K/AKT pathway through epigenetic silencing of its negative regulator PTEN gene.

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