Daniela Stoppoloni, Irene Cardillo, Alessandra Verdina, Bruno Vincenzi, Simona Menegozzo, Mario Santini, Ada Sacchi, Alfonso Baldi and Rossella Galati Expression of the embryonic lethal abnormal vision-like protein HuR in human mesothelioma Cancer 113
Version of Record online: 2 OCT 2008 | DOI: 10.1002/cncr.23904
Cytokine treatment can induce a shift in cytosolic levels of the human embryonic lethal abnormal vision (ELAV)-like protein HuR in some mesothelioma cell lines that is accompanied by an increase in cyclooxygenase-2 (COX-2) messenger RNA and protein levels. In a group of 29 human mesothelioma tissues, the authors demonstrated a positive, statistically significant correlation between high COX-2 expression and cytoplasmic localization of HuR (P = .016). Moreover, on univariate analysis, overall survival was influenced strongly by cytoplasmic HuR localization (P = .004). The results of the current study suggested that HuR plays a role in tumor progression in mesothelioma and that COX-2 may be a target of its activity in neoplastic cells.
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