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Stacy Moulder, Nickola Valkov, Anthony Neuger, Jimin Choi, Ji Hyun Lee, Susan Minton, Pamela Munster, Jana Gump, Mira Lacevic, Richard Lush and Dan Sullivan Phase 2 study of gemcitabine and irinotecan in metastatic breast cancer with correlatives to determine topoisomerase I localization as a predictor of response Cancer 113

Article first published online: 29 SEP 2008 | DOI: 10.1002/cncr.23916

The combination of gemcitabine and irinotecan was associated with a 25% response rate in patients with advanced pretreated breast cancer. Topoisomerase localization can be measured in breast cancer cells obtained by fine-needle aspiration.

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