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Marios E. Froudarakis, Athanasia Pataka, Periklis Pappas, Stavros Anevlavis, Evangelia Argiana, Martha Nikolaidou, George Kouliatis, Sofia Pozova, Marios Marselos and Demosthenes Bouros Phase 1 trial of lipoplatin and gemcitabine as a second-line chemotherapy in patients with nonsmall cell lung carcinoma Cancer 113

Article first published online: 29 SEP 2008 | DOI: 10.1002/cncr.23921

Lung cancer remains the most common fatal malignancy. Despite more aggressive therapies, to date only a slight improvement in survival has been obtained. Lipoplatin is a new liposomal cisplatin that already has been tested in solid tumors, with encouraging results. The purpose of the current study was to determine the maximum tolerated dose and dose-limiting toxicity of a 21‒day regimen of lipoplatin plus a fixed dose of gemcitabine in patients with refractory or resistant nonsmall cell lung carcinoma.

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