Anna K. Wong, Raymond C. Chan, W. Stephen Nichols and Shikha Bose Invader human papillomavirus (HPV) type 16 and 18 assays as adjuncts to HPV screening of cervical papanicolaou smears with atypical squamous cells of undetermined significance Cancer 115
Version of Record online: 6 JAN 2009 | DOI: 10.1002/cncr.24091
The typing of Papanicolaou smears with high-risk, human papillomavirus (HPV)-positive, atypical squamous cells for HPV type 16 (HPV-16) was used to stratify women into 3 risk categories. Women who were positive for HPV-16 had a 54% risk of developing cervical intraepithelial neoplasia 2 (CIN-2)/CIN-3, women who were positive for non-HPV-16 HPV types had a 9% risk of developing CIN-2/CIN-3, and women who were negative for HPV had a negligible risk of developing CIN-2/CIN-3. The results indicated the potential for tailored management of these women.
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