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Christopher J. Weight, Jorge A. Garcia, Donna E. Hansel, Amr F. Fergany, Steven C. Campbell, Michael C. Gong, J. Stephen Jones, Eric A. Klein, Robert Dreicer and Andrew J. Stephenson Lack of pathologic down-staging with neoadjuvant chemotherapy for muscle-invasive urothelial carcinoma of the bladder Cancer 115

Version of Record online: 6 JAN 2009 | DOI: 10.1002/cncr.24106

The survival benefit of neoadjuvant chemotherapy (NC) after open radical cystectomy (RC) was evaluated in a contemporary cohort of patients in a tertiary referral setting. Few RC patients achieved a pathologic complete response with NC, and most experienced rapid disease progression. These poor outcomes may be related to the use of certain regimens or excessive delay in performing RC. Excessive delays in performing RC may negate the benefit of NC.

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