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Manoj Garg, Deepika Kanojia, Sushma Suri and Anil Suri Small interfering RNA-mediated down-regulation of SPAG9 inhibits cervical tumor growth Cancer 115

Article first published online: 7 OCT 2009 | DOI: 10.1002/cncr.24658

Earlier work revealed a significant association of SPAG9 expression in the early spread of cervical cancer, making it an attractive therapeutic target. A small interfering RNA approach was used to specifically knock down the expression of SPAG9. Findings demonstrated that knockdown of SPAG9 expression by small interfering RNA significantly suppressed cellular motility and tumor growth of cervical squamous cell carcinoma in vivo. Small interfering RNA-mediated down-regulation of SPAG9 represents a promising therapeutic approach for the treatment of cervical cancer.

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