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Sue C. Kaste, Pamela Goodman, Wendy Leisenring, Marilyn Stovall, Robert J. Hayashi, Mark Yeazel, Soraya Beiraghi, Melissa M. Hudson, Charles A. Sklar, Leslie L. Robison and K. Scott Baker Impact of radiation and chemotherapy on risk of dental abnormalities Cancer 115

Version of Record online: 15 OCT 2009 | DOI: 10.1002/cncr.24670

Controlling for chemotherapy and socioeconomic factors, radiation exposure of ≥20 Gray to dentition was associated significantly with an increased risk of >1 dental abnormality. Dose-dependent alkylating agent therapy significantly increased the risk of >1 anatomic/developmental dental abnormalities in survivors who were diagnosed at ages <5 years (odds ratios, 1.7, 2.7, and 3.3 for alkylating agent scores of 1, 2, and 3, respectively).

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