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Hagop Youssoufian, Eric K. Rowinsky, James Tonra and Yiwen Li Targeting FMS-related tyrosine kinase receptor 3 with the human immunoglobulin G1 monoclonal antibody IMC-EB10 Cancer 116

Version of Record online: 2 FEB 2010 | DOI: 10.1002/cncr.24787

FMS-related tyrosine kinase receptor 3 (FLT3)-directed agents hold considerable promise in hematologic malignancies. IMC-EB10, a fully human monoclonal antibody targeting FLT3, was active in leukemia preclinical models and was the first antibody to enter clinical development in this setting.

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