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Jonathan D. Schwartz, Eric K. Rowinsky, Hagop Youssoufian, Bronislaw Pytowski and Yan Wu Vascular endothelial growth factor receptor-1 in human cancer Cancer 116

Version of Record online: 2 FEB 2010 | DOI: 10.1002/cncr.24789

Vascular endothelial growth factor receptor-1 (VEGFR-1) mediated signaling contributes to cancer pathogenesis by means of both direct growth stimulation and activation of endothelial, stromal, progenitor, and other cells. Antibody-mediated inhibition of VEGFR-1 represents a promising anti-cancer strategy and preliminary clinical studies investigating IMC-18F1 in humans indicate a favorable safety profile.

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