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Rébécca Phaeton, Xing Guo Wang, Mark H. Einstein, Gary L. Goldberg, Arturo Casadevall and Ekaterina Dadachova The influence of proteasome inhibitor MG132, external radiation, and unlabeled antibody on the tumor uptake and biodistribution of 188Re-labeled anti-E6 C1P5 antibody in cervical cancer in mice Cancer 116

Version of Record online: 2 FEB 2010 | DOI: 10.1002/cncr.24794

The efficacy of radioimmunotherapy (RIT) targeting viral oncoprotein E6 in the treatment of human papillomavirus (HPV) type 16 (HPV‒16)-related and HPV18-related cervical cancer would depend on the level and accessibility of intranuclear E6 protein in the tumor. The authors demonstrated that pretreatment of CasKi HPV16-positive tumors in mice with proteasome inhibitor MG132 significantly increased the uptake of radiolabeled anti-E6 antibody in the tumor and cleared quickly from all normal tissues.

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