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Nikolai Velev, Jorge Cortes, Richard Champlin, Dan Jones, Gabriela Rondon, Sergio Giralt, Gautam Borthakur, Hagop M. Kantarjian and Marcos De Lima Stem cell transplantation for patients with chronic myeloid leukemia resistant to tyrosine kinase inhibitors with BCR-ABL kinase domain mutation T315I Cancer 116

Version of Record online: 5 MAY 2010 | DOI: 10.1002/cncr.25092

This report, to the authors' knowledge, is the first to describe a series patients with chronic myeloid leukemia (CML) who had a threonine-to-isoleucine mutation at codon 315 (T315I) of the breakpoint cluster region/v-abl Abelson murine leukemia viral oncogene protein fusion (Bcr-Abl) and underwent stem cell transplantation (SCT). The outcomes presented suggest that SCT represents an effective treatment strategy for patients with this abnormality.

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