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François Bertucci, Pascal Finetti, Daniel Birnbaum and Patrice Viens Gene expression profiling of inflammatory breast cancer Cancer 116

Article first published online: 19 MAY 2010 | DOI: 10.1002/cncr.25165

Inflammatory breast cancer (IBC) is a rare but aggressive form of breast cancer, and its molecular basis is poorly elucidated. New high-throughput gene expression profiling technologies have been applied recently to small and heterogeneous series of clinical samples and have revealed the great transcriptional heterogeneity of IBC; the existence of molecular subtypes similar to non-IBC; differences in gene expression levels between IBC and non-IBC variables across studies; and, to date, no gene overlap across the reported signatures. In the future, larger series of IBC samples that are selected using homogeneous criteria must be profiled, and the current results call for urgent international collaborations.

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