Fredika M. Robertson, Wendy A. Woodward, Ross Pickei, Zaiming Ye, William Bornmann, Ashutosh Pal, Zhenghong Peng, Carolyn S. Hall and Massimo Cristofanilli Suberoylanilide hydroxamic acid blocks self-renewal and homotypic aggregation of inflammatory breast cancer spheroids Cancer 116
The pan-histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA; vorinostat) blocked self-renewal and homotypic aggregation of inflammatory breast cancer (IBC) tumor spheroids, leading to loss of the integrity of these 3 dimensional structures. Although SAHA did not alter the total amount of E-cadherin protein, it induced a change in location from the plasma membrane to the cytoplasm. SAHA is the first agent shown to be capable of altering the structure and functions of IBC tumor spheroids, which serve as in vitro surrogates of IBC tumor emboli that are the classic pathological signatures of IBC. These studies suggest that SAHA warrants further evaluation for its therapeutic effects in IBC, the most aggressive form of locally advanced breast cancer.
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