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Mei Wu, Zhi-fen Wu, Devin T. Rosenthal, Elliot M. Rhee and Sofia D. Merajver Characterization of the roles of RHOC and RHOA GTPases in invasion, motility, and matrix adhesion in inflammatory and aggressive breast cancers Cancer 116

Version of Record online: 19 MAY 2010 | DOI: 10.1002/cncr.25181

The 2 closely related small GTPases, RHOC and RHOA, are involved in mammary gland carcinogenesis. By selectively knocking down these proteins, we have been able to show that RHOC, and not RHOA, modulates surface expression and colocalization of α2 and β1 integrins in MDA-MB-231 on collagen I, suggesting that RHOC and RHOA play different roles in cell-matrix adhesion, motility, and invasion of MDA-MB-231. Neither RHOC or RHOA affected integrin expression in the inflammatory breast cancer cell line SUM149, further highlighting the different regulation of adhesion and motility in inflammatory breast cancer.

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