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Esther C. de Haas, Nynke Zwart, Coby Meijer, Albert J.H. Suurmeijer, Karina Meijer, Henk-Jan Guchelaar, Harald J. Hoekstra, Flora E. van Leeuwen, Dirk Th. Sleijfer, H. Marike Boezen and Jourik A. Gietema Association of PAI-1 gene polymorphism with survival and chemotherapy-related vascular toxicity in testicular cancer Cancer 116

Version of Record online: 24 AUG 2010 | DOI: 10.1002/cncr.25300

In this study the common 4G/4G variant of PAI-1 4G/5G gene polymorphism is associated with reduced cancer-related survival in testicular cancer patients treated with platinum-based chemotherapy. This observation suggests that PAI-1 (4G/5G polymorphism) may be an additional biomarker in testicular cancer and contribute to the identification of patients who are at increased risk of not responding to standard chemotherapy.

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