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Pier Luigi Zinzani, Alessandro Broccoli, Vittorio Stefoni, Gerardo Musuraca, Elisabetta Abruzzese, Amalia De Renzo, Maria Cantonetti, Francesco Bacci, Michele Baccarani and Stefano A. Pileri Immunophenotype and intermediate-high international prognostic index score are prognostic factors for therapy in diffuse large B-cell lymphoma patients Cancer 116

Version of Record online: 24 AUG 2010 | DOI: 10.1002/cncr.25307

This study investigated the role of immunohistochemical discrimination between germinal center B-cell (GCB) and activated B-cell and not classified (ABC&NC) diffuse large B-cell lymphoma (DLBCL) subtypes in identifying those high-risk patients who may benefit from a more aggressive first-line therapeutic approach. The authors determined that an autologous stem cell transplantation consolidation in the ABC&NC-DLBCL subtypes induces the same rate of complete response and similar progression-free survival rate compared with GCB-DLBCL. In ABC&NC-DLBCL patients, the authors observed a complete response rate of 89.7% versus 84.6% reported in GCB-DLBCL subset, without any significant difference in progression-free survival rate.

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