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Deborah Thomas, Susan O'Brien, Stefan Faderl, Farhad Ravandi, Elias Jabbour, Sherry Pierce, Jorge Cortes and Hagop Kantarjian Anthracycline dose intensification in adult acute lymphoblastic leukemia Cancer 116

Version of Record online: 19 AUG 2010 | DOI: 10.1002/cncr.25319

Sixty-eight patients with newly diagnosed acute lymphoblastic leukemia or lymphoblastic lymphoma received the hyper-CVAD regimen (hyper-fractionated cyclophosphamide, vincristine, doxorubicin and dexamethasone alternating with high dose methotrexate and cytarabine) with the addition of high-dose liposomal daunorubicin as postremission consolidation therapy (Course 2). The incorporation of early anthracycline intensification did not improve outcome.

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