Wen-Chun Chang, Chao-Hsu Li, Su-Cheng Huang, Daw-Yuan Chang, Li-Yun Chou and Bor-Ching Sheu Clinical significance of regulatory T cells and CD8+ effector populations in patients with human endometrial carcinoma Cancer 116
Version of Record online: 23 AUG 2010 | DOI: 10.1002/cncr.25371
Regulatory T cells in the tumor microenvironment may abrogate CD8+ T cell cytotoxicity in a granzyme B- and perforin-dependent conduit. Of clinical significance, the expression of regulatory T cells in tumor-infiltrating lymphocytes may mediate T cell immune repression within cancer milieu and thus greatly correlate with cancer progression.
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