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Heather Magnan, Alexander J. Chou, Joanne F. Chou, Henry W.D. Yeung, John H. Healey and Paul A. Meyers Noninvasive imaging with thallium-201 scintigraphy may not correlate with survival in patients with osteosarcoma Cancer 116

Version of Record online: 19 AUG 2010 | DOI: 10.1002/cncr.25375

Although thallium-201 (T1-201) scintigraphic response to preoperative chemotherapy has previously been shown to correlate with histologic response, in this series of 22 patients with osteosarcoma, Tl-201 scintigraphic response to preoperative chemotherapy did not appear to correlate with event-free survival. It is necessary to use robust outcome variables and not rely on surrogates for outcome to evaluate potential prognostic factors.

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