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Henry M. Kuerer, Aman U. Buzdar, Elizabeth A. Mittendorf, Francisco J. Esteva, Anthony Lucci, Luis M. Vence, Laszlo Radvanyi, Funda Meric-Bernstam, Kelly K. Hunt and William Fraser Symmans Biologic and immunologic effects of preoperative trastuzumab for ductal carcinoma in situ of the breast Cancer 117

Version of Record online: 24 AUG 2010 | DOI: 10.1002/cncr.25399

Single-dose preoperative monotherapy with trastuzumab for patients with HER2-positive DCIS results in the early ability to mount antibody dependent cellular cytotoxicity mediated through natural killer cells and may also induce T-cell dependent humoral immunity.

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