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Matthew R. Cooperberg, Andrew J. Vickers, Jeanette M. Broering, Peter R. Carroll and for the Cancer of the Prostate Strategic Urologic Research Endeavor (CaPSURE) Investigators Comparative risk-adjusted mortality outcomes after primary surgery, radiotherapy, or androgen-deprivation therapy for localized prostate cancer Cancer 116

Version of Record online: 3 NOV 2010 | DOI: 10.1002/cncr.25456

In a large, prospectively accrued cohort of patients who were followed under uniform protocols regardless of initial therapy, the authors observed statistically significant, adjusted differences in cancer-specific and overall mortality among men who underwent radical prostatectomy, men who received external-beam radiation therapy, and men who received primary androgen-deprivation monotherapy. These differences were more prominent at higher levels of risk, they were robust to multiple sensitivity analyses, and they suggested that surgery should play a greater role as part of multimodal therapy for patients with high-risk prostate cancer.

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