Shahana Majid, Altaf A. Dar, Sharanjot Saini, Soichiro Yamamura, Hiroshi Hirata, Yuichiro Tanaka, Guoren Deng and Rajvir Dahiya MicroRNA-205–directed transcriptional activation of tumor suppressor genes in prostate cancer Cancer 116
Article first published online: 24 AUG 2010 | DOI: 10.1002/cncr.25488
MicroRNA-205 functions as a tumor suppressor by up-regulating the interleukin (IL) tumor suppressor genes IL24 and IL32 and targeting specific sites in their promoters. The identification this phenomenon in which cancer cells can be targeted with microRNA to turn on silenced tumor suppressor genes may have significant therapeutic potential in the treatment of prostate cancer.
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