Han-Shui Hsu, Jiun-Han Lin, Wen-Chien Huang, Tien-Wei Hsu, Kelly Su, Shih-Hwa Chiou, Yo-Ting Tsai and Shih-Chieh Hung Chemoresistance of lung cancer stemlike cells depends on activation of Hsp27 Cancer 117
Article first published online: 8 NOV 2010 | DOI: 10.1002/cncr.25599
Lung cancer stem cells have elevated levels of activated Hsp27 upon treatment with superoxide and traditional chemotherapy. When combined with chemotoxic agents, blockage of Hsp27 decreased the survival of lung cancer stem cells, which otherwise were resistant to traditional chemotherapy.
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