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Lijun Tan, Roland P. Kwok, Abhishek Shukla, Malti Kshirsagar, Lili Zhao, Anthony W. Opipari Jr and J. Rebecca Liu Trichostatin A restores Apaf-1 function in chemoresistant ovarian cancer cells Cancer 117

Version of Record online: 5 OCT 2010 | DOI: 10.1002/cncr.25649

Resistance of ovarian cancer cells to the proapoptotic effects of chemotherapy is due in part to deficient Apaf-1 activity. Trichostatin A restores Apaf-1 function independent of alterations in Apaf-1 expression.

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