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Najat C. Daw, Michael D. Neel, Bhaskar N. Rao, Catherine A. Billups, Jianrong Wu, Jesse J. Jenkins, Juan Quintana, Lori Luchtman-Jones, Milena Villarroel and Victor M. Santana Frontline treatment of localized osteosarcoma without methotrexate Cancer 117

Article first published online: 10 JAN 2011 | DOI: 10.1002/cncr.25715

The treatment of localized, resectable osteosarcoma with carboplatin, ifosfamide, and doxorubicin produces event-free survival and survival results that are comparable to those of cisplatin-containing or high-dose methotrexate (HDMTX)-containing regimens. This regimen offers a good alternative for patients, particularly those who demonstrate intolerance of HDMTX, and for institutions that cannot provide MTX monitoring.

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