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Elizabeth Van Tubergen, Robert Vander Broek, Julia Lee, Gregory Wolf, Thomas Carey, Carol Bradford, Mark Prince, Keith L. Kirkwood and Nisha J. D'Silva Tristetraprolin regulates interleukin-6, which is correlated with tumor progression in patients with head and neck squamous cell carcinoma Cancer 117

Version of Record online: 10 JAN 2011 | DOI: 10.1002/cncr.25859

Tristetraprolin (TTP), a protein that decreases the stability of messenger RNA (mRNA) of cytokines and proinflammatory factors, is reduced in patients with head and neck squamous cell carcinoma with a corresponding increase in interleukin-6 (IL-6), vascular endothelial growth factor, and cyclooxygenase-2 secretion. One of these tumor-derived cytokines, IL-6, is prognostic for poor disease-specific survival, tumor recurrence, second primary lesions, and poor overall survival.

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