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Jilong Yang, Da Yang, Yan Sun, Baocun Sun, Guowen Wang, Jonathan C. Trent, Dejka M. Araujo, Kexin Chen and Wei Zhang Genetic amplification of the vascular endothelial growth factor (VEGF) pathway genes, including VEGFA, in human osteosarcoma Cancer 117

Article first published online: 14 APR 2011 | DOI: 10.1002/cncr.26116

By using integrated microarray-based comparative genomic hybridization (aCGH), fluorescent in situ hybridization (FISH), and immunohistochemistry analyses, the authors identified genetic amplification of vascular endothelial growth factor (VEGF) pathway genes and validated VEGFA gene amplification in human osteosarcoma, either focally or in larger fragments.

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