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Daniel Albo, Catherine L. Akay, Christy L. Marshall, Jonathan A. Wilks, Gordana Verstovsek, Hao Liu, Neeti Agarwal, David H. Berger and Gustavo E. Ayala Neurogenesis in colorectal cancer is a marker of aggressive tumor behavior and poor outcomes Cancer 117

Article first published online: 8 APR 2011 | DOI: 10.1002/cncr.26117

The results from this study provided evidence of neurogenesis in vitro and in vivo; specifically, the authors report the phenomenon of neurogenesis in colorectal cancer and its association with aggressive stages of colorectal cancer. Neurogenesis was indicative of poor survival and recurrence and was an independent prognostic factor for poor outcomes in patients with colorectal cancer. The authors concluded that neurogenesis offers the potential for better therapy stratification of patients with lymph node-negative colorectal cancer.

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