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Filippo Montemurro, Valentina Rossi, Maria Cossu Rocca, Rossella Martinello, Elena Verri, Stefania Redana, Laura Adamoli, Giorgio Valabrega, Anna Sapino, Massimo Aglietta, Giuseppe Viale, Aron Goldhirsch and Franco Nolè Hormone-receptor expression and activity of trastuzumab with chemotherapy in HER2-positive advanced breast cancer patients Cancer 118

Version of Record online: 19 MAY 2011 | DOI: 10.1002/cncr.26162

The authors evaluated the predictive value of quantitative hormone receptor expression in patients with HER2-positive advanced breast cancer receiving trastuzumab and chemotherapy. Whereas high hormone receptor expression predicted reduced response rate, hormone receptor positivity was associated with a large progression-free survival benefit when endocrine therapy was added to trastuzumab after chemotherapy.

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