Junhong Zhao, Hongchuan Jin, Kin Fai Cheung, Joanna H. M. Tong, Sui Zhang, Minnie Y. Y. Go, Linwei Tian, Wei Kang, Patrick P. S. Leung, Zhirong Zeng, Xiaoxing Li, Ka Fai To, Joseph J. Y. Sung and Jun Yu Zinc finger E-box binding factor 1 plays a central role in regulating Epstein-Barr virus (EBV) latent-lytic switch and acts as a therapeutic target in EBV-associated gastric cancer Cancer 118
Article first published online: 29 JUN 2011 | DOI: 10.1002/cncr.26184
The authors studied the effects of zinc finger E-box binding factor 1 (ZEB1) on the latent-lytic switch of Epstein-Barr virus (EBV) infection in gastric cancer and explored the importance of EBV in gastric carcinogenesis. The results indicated that ZEB1 is a key mediator of the latent-lytic switch of EBV-associated gastric cancer, a distinct subtype with different clinicopathologic features, and ZEB1 may be a potential target for EBV-associated gastric cancer therapy.
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