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Patricia K. Corey-Lisle, Ronald Peck, Pralay Mukhopadhyay, Lucinda Orsini, Shima Safikhani, Jill A. Bell, Gabriel Hortobagyi, Henri Roche, Pierfranco Conte and Dennis A. Revicki Q-TWiST analysis of ixabepilone in combination with capecitabine on quality of life in patients with metastatic breast cancer Cancer 118

Article first published online: 19 MAY 2011 | DOI: 10.1002/cncr.26213

The current study evaluated the trade-off between quality and quantity of life using quality-adjusted time without symptoms or toxicity (Q-TWiST) outcomes for the combination of ixabepilone and capecitabine (cape) versus cape alone in patients with locally advanced/metastatic breast cancer. The Q-TWiST analysis was found to support a positive benefit-risk ratio for the combination of ixabepilone plus cape in patients with advanced/metastatic breast cancer that was refractory to anthracyclines and taxanes compared with cape monotherapy alone, despite the potential for added toxicities with combination therapy.

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