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Jinliang Xing, Colin P. Dinney, Sanjay Shete, Maosheng Huang, Michelle A. Hildebrandt, Zhinan Chen and Jian Gu Comprehensive pathway-based interrogation of genetic variations in the nucleotide excision DNA repair pathway and risk of bladder cancer Cancer 118

Article first published online: 20 JUN 2011 | DOI: 10.1002/cncr.26224

In this large cancer association study, the authors identified several novel genetic predisposition variants in nucleotide excision repair pathway genes for bladder cancer and observed potential gene-gene and gene-environment interactions. The results reinforce the importance of a comprehensive, pathway-focused, and tagging single nucleotide polymorphism-based candidate gene approach to identify low-penetrance cancer-susceptibility loci.

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