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Li-Chung Chuang, Chung-Yi Hu, Hui-Chi Chen, Pei-Jung Lin, Borheng Lee, Ching-Yu Lin, Mei-Hung Pan, San-Lin You, Chang-Yao Hsieh, Chien-Jen Chen and Community-Based Cancer Screening Program-Human Papillomavirus Study Group Associations of human leukocyte antigen class II genotypes with human papillomavirus 18 infection and cervical intraepithelial neoplasia risk Cancer 118

Version of Record online: 20 JUN 2011 | DOI: 10.1002/cncr.26227

Human leukocyte antigen alleles DRB1*0403 and DRB1*0405 are, respectively, associated with the high viral load and persistent infection of human papillomavirus type 18 (HPV18). The DRB1*0403 allele is associated with an increased risk of developing high-grade squamous intraepithelial lesions or cervical cancer after adjustment for viral load and persistent infection of HPV18.

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