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Lee E. Moore, Ruth M. Pfeiffer, Zhen Zhang, Karen H. Lu, Eric T. Fung and Robert C. Bast Jr. Proteomic biomarkers in combination with CA 125 for detection of epithelial ovarian cancer using prediagnostic serum samples from the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial Cancer 118

Version of Record online: 29 JUN 2011 | DOI: 10.1002/cncr.26241

In a study that investigated prediagnostically collected sera from a group of 118 women with invasive ovarian cancer and a control group of 951 healthy women who participated in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial, analytical models that included cancer antigen 125 (CA 125) and 7 biomarkers failed to improve on the sensitivity of CA 125 alone. This was in contrast to observations in previous studies using postdiagnostically collected serum samples, in which improved sensitivity was observed with the addition of proteomic biomarkers to CA 125 alone.

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