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Jennifer K. Litton, Kaylene Ready, Huiqin Chen, Angelica Gutierrez-Barrera, Carol J. Etzel, Funda Meric-Bernstam, Ana M. Gonzalez-Angulo, Huong Le-Petross, Karen Lu, Gabriel N. Hortobagyi and Banu K. Arun Earlier age of onset of BRCA mutation-related cancers in subsequent generations Cancer 118

Version of Record online: 12 SEP 2011 | DOI: 10.1002/cncr.26284

Women with mutations in the breast cancer (BRCA) genes BRCA1 or BRCA2 have a high lifetime risk of developing breast cancer, and more intense screening and prophylactic measures are used. The results of this study indicated that, in families with a known deleterious BRCA mutation, women were being diagnosed overall 7.9 years earlier than in the preceding generation.

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