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Amal Melhem-Bertrandt, Jasmina Bojadzieva, Kaylene J. Ready, Elias Obeid, Diane D. Liu, Angelica M. Gutierrez-Barrera, Jennifer K. Litton, Olufunmilayo I. Olopade, Gabriel N. Hortobagyi, Louise C. Strong and Banu K. Arun Early onset HER2-positive breast cancer is associated with germline TP53 mutations Cancer 118

Version of Record online: 14 JUL 2011 | DOI: 10.1002/cncr.26377

Germline TP53 mutations lead to early onset breast cancer and are associated with Li-Fraumeni syndrome. There are limited data on the pathological characteristics of these cancers. In this article, we describe an association between breast cancer in patients with germline TP53 mutation and human epidermal growth factor receptor 2 overexpression.

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