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Kathryn P. Lowry, Janie M. Lee, Chung Y. Kong, Pamela M. McMahon, Michael E. Gilmore, Jessica E. Cott Chubiz, Etta D. Pisano, Constantine Gatsonis, Paula D. Ryan, Elissa M. Ozanne and G. Scott Gazelle Annual screening strategies in BRCA1 and BRCA2 gene mutation carriers Cancer 118

Version of Record online: 20 SEP 2011 | DOI: 10.1002/cncr.26424

A Markov Monte Carlo simulation model was used to compare the life expectancy gains of various annual breast cancer screening strategies in women with BRCA1/BRCA2 mutations, including the risk of radiation-induced cancers. The results suggest that screening with annual magnetic resonance imaging starting at age 25 years with delayed, alternating digital mammography starting at age 30 years is probably the most effective screening strategy in BRCA mutation carriers.

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