Soley Bayraktar, Nisreen Elsayegh, Angelica M. Gutierrez Barrera, Heather Lin, Henry Kuerer, Tunc Tasbas, Kimberly I. Muse, Kaylene Ready, Jennifer Litton, Funda Meric-Bernstam, Gabriel N. Hortobagyi, Constance T. Albarracin and Banu Arun Predictive factors for BRCA1/BRCA2 mutations in women with ductal carcinoma in situ Cancer 118
Article first published online: 25 AUG 2011 | DOI: 10.1002/cncr.26428
Of 118 high-risk women with ductal carcinoma in situ (DCIS), 27% (n = 32) test positive for breast cancer-susceptibility gene (BRCA1/BRCA2) mutations. Women who have DCIS and a family history of at least 2 relatives affected with ovarian cancer or who have scores ≥10% according to BRCAPRO (a mathematical model for calculating the probability that a particular family member carries a germline BRCA mutation) have high rates of BRCA positivity regardless of their age at diagnosis.
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