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Sunphil Jang, Young Tae Kim, Hye Won Chung, Kyoung-Ryul Lee, Jong-Baeck Lim and Kyungwon Lee Identification of novel immunogenic human leukocyte antigen-A*2402-binding epitopes of human papillomavirus type 16 E7 for immunotherapy against human cervical cancer Cancer 118

Article first published online: 14 SEP 2011 | DOI: 10.1002/cncr.26468

Peripheral blood mononuclear cells (PBMCs) and CD8+ cytotoxic T lymphocytes sensitized with newly identified human papillomavirus type 16 E761-69 and E767-76 epitopes for human leukocyte antigen-A*2402 have cytolytic activity and antitumor effects against cervical cancer. Treatment with cisplatin followed by peptide-sensitized PBMCs generates a more potent and long-term antitumor effect than treatment with cisplatin alone.

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