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Gangxiong Huang, Zhichao Zhou, Hua Wang and Eugenie S. Kleinerman CAPER-α alternative splicing regulates the expression of vascular endothelial growth factor165 in Ewing sarcoma cells Cancer 118

Article first published online: 25 AUG 2011 | DOI: 10.1002/cncr.26488

The overexpression of vascular endothelial growth factor165 in some Ewing tumors may be mediated by a switch from the 189 isoform to the 165 isoform, which is secondary to the down-regulation of CAPER-α. EWS/FLI-1 may control the transcription of CAPER-α, resulting in its down-regulation in Ewing sarcoma cells.

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