Gad Rennert, Flavio Lejbkowicz, Ilana Cohen, Mila Pinchev, Hedy S. Rennert and Ofra Barnett-Griness MutYH mutation carriers have increased breast cancer risk Cancer 118
Article first published online: 22 SEP 2011 | DOI: 10.1002/cncr.26506
Heterozygosity for the mutY homolog gene MutYH is associated with close to doubling of the risk for breast cancer in a population that has a high prevalence of mutations in this gene. Although some former reports suggested such an association in highly selected cancer families, the authors manage to demonstrate it in a population-based study of the general population. The findings can help identify women at risk for preventive interventions.
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