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May Tsao, Wei Xu and Arjun Sahgal A meta-analysis evaluating stereotactic radiosurgery, whole-brain radiotherapy, or both for patients presenting with a limited number of brain metastases Cancer 118

Article first published online: 1 SEP 2011 | DOI: 10.1002/cncr.26515

We provide updated hazard ratios on overall survival, local control, and distant brain control by pooling those randomized studies comparing whole-brain radiation plus radiosurgery boost to whole-brain radiotherapy alone or radiosurgery alone. We conclude no overall survival advantage to whole-brain radiotherapy despite higher rates of local control and distant brain control when added to radiosurgery; furthermore, as additional whole-brain radiation may harm neurocognition and increase the risk of late side effects, the option of radiosurgery alone should be routinely considered for selected patients.

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