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Jiro Ichikawa, Heather A. Cole, Robert A. Magnussen, Nicholas A. Mignemi, Matthew Butler, Ginger E. Holt, Lynda O'Rear, Masato Yuasa, Baldeep Pabla, Hirotaka Haro, Justin M. M. Cates, Heidi E. Hamm, Herbert S. Schwartz and Jonathan G. Schoenecker Thrombin induces osteosarcoma growth, a function inhibited by low molecular weight heparin in vitro and in vivo Cancer 118

Article first published online: 27 SEP 2011 | DOI: 10.1002/cncr.26518

Osteosarcoma cells express cofactors and receptors of the coagulation cascade that directly and indirectly promote a malignant phenotype by increasing cell proliferation and forming a thrombus. Osteosarcoma growth can be attenuated by targeting this procoagulant activity with low molecular weight heparin.

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