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Andrew Chi, Samir P. Shirodkar, Diogo O. Escudero, Obi O. Ekwenna, Travis J. Yates, Rajinikanth Ayyathurai, Michael Garcia-Roig, Jeffrey C. Gahan, Murugesan Manoharan, Vincent G. Bird and Vinata B. Lokeshwar Molecular characterization of kidney cancer Cancer 118

Article first published online: 1 SEP 2011 | DOI: 10.1002/cncr.26520

Among the 12 hyaluronic acid (HA) family members, which include HA synthases, hyaluronidases, and HA receptors, CD44s and RHAMM mRNA levels are significantly elevated in renal cell carcinoma subtypes when compared with normal kidney and oncocytoma specimens, regardless of the tumor size. In this study CD44s, RHAMM and combined CD44s + RHAMM markers independently predict metastasis with >80% accuracy.

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